pylori.Ī 1996 article published in the New England Journal of Medicine followed two groups of people who were being treated for reflux esophagitis for a period of five years. Prilosec and other acid suppressing drugs increase gastritis (inflammation of the stomach) and epithelial lesions in the corpus of the stomach in people infected with H. ![]() pylori infections and increase rates of infection. ![]() pylori infection, we might expect acid suppressing drugs to worsen current H. If low stomach acid is a prerequisite to H. pylori infection increases with age, it follows that hypochlorhydria also increases with age. However, this tendency for acid secretion to increase with age is completely nullified by the corresponding increase in H. pylori with antibiotics improves nearly all patients suffering from hypochlorhydria.Īlthough it is commonly assumed that stomach acid production declines with age, recent studies suggest that the secretion of stomach acid doesn’t decrease with age and that the trend is actually to increase, especially in men. pylori infection with antibiotics increases stomach acidity and eradicating H. In fact, this is how it survives in the hostile acidic environment of the stomach, which would ordinarily kill all bacteria. pylori suppresses stomach acid secretion. So we can expect that approximately 80% of 80 year-olds are infected with H. In general, the prevalence of infection raises 1% with every year of life. Statistics indicate that more than 50% of the world population is infected. pylori is the most common chronic bacterial pathogen in humans. pylori infection plays a significant role in the pathogenesis of GERD and other digestive disorders. pylori infection in GERD patients was found to be greater than in non- GERD patients. pylori infection in GERD and IBS patients could be a target of future research, as in the present study the prevalence of H. I think they’re on to something!Īssessing the role of H. The authors even speculate that the underlying cause may be an overgrowth of bacteria. This finding shows that in overlapping GERD and IBS, other functional abnormalities of the GI tract are also highly prevalent, suggesting a common underlying dysfunction. What this correspondence suggests, of course, is exactly what I argued in the last article: that IBS and GERD may very well share a common etiology and underlying mechanism. Implications of the Connection between GERD and IBS They also found that the prevalence of all functional symptoms (such as nausea, changes in bowel movement, headache, etc.) was higher in overlapping GERD and IBS subjects than the prevalence in GERD subjects without IBS or IBS subjects without GERD. The authors found that 64% of IBS subjects studied also had GERD, whereas 34% of the GERD patients also had IBS. To my knowledge it’s the largest data set that has been reported about the overlap between GERD and IBS. ![]() The data comes from a very large number of patients (6,476). Malekzadeh & Moghaddam performed a retrospective study to investigate the prevalence of GERD in patients with IBS and vice versa. Before moving on to my next planned article in the series, I want to take some time to review this study and discuss its implications. Right after publishing yesterday’s article ( The hidden causes of heartburn and GERD), I came across a new research ( PDF) study hot off the presses that adds support to the theory that GERD is caused in part by bacterial overgrowth. If you haven’t done so already, you’ll want to read Part I and Part II before reading this article. Note: this is the third article in a series about heartburn and GERD.
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